Wednesday, December 26, 2007

Scientific Methods to Reduce Breast and Prostate Cancer Risk

Failure to understand the basic cause of a disease can negate the effects of well-meaning prevention strategies. At any given time, popular myths surround the real causes of human disorders.

While you may have heard all kinds of reasons why increasing numbers of people are contracting cancer, the underlying cause (that few doctors address) is the aging process itself.1

One reason this fundamental cause has been neglected is that up until recently, there was little one could do to protect against this proven risk factor.

In this article, we are going to explain how aging increases cancer risk and what you can do to protect against this pathological phenomenon.

To enable you to fully understand the carcinogenic effects of aging, we have reprinted on this page a chart showing women’s breast cancer risk by age.

A quick look at this chart clearly documents that aging is the underlying cause of breast cancer. Next we are going to tell you why and what you can do to protect yourself.

An article published in the New England Journal of Medicine titled “Roads Leading to Breast Cancer” provides a great one sentence explanation of why aging cells are vulnerable to cancer. Here is that sentence:

“Cancer results from the accumulation of mutations in genes that regulate cellular proliferation.”3

In this one sentence, you have just learned why people contract more cancer as they grow older.

To clarify this further, please understand that every time a cell divides, slight mutations occur to the genes that regulate cellular proliferation.

Furthermore, mutations to genes happen in response to direct insult from ionizing radiation. The longer you live, the more gene mutations you encounter.

Once too many regulatory genes become mutated, cells lose normal regulatory control and can turn into cancer cells.

So a basic prevention strategy is to do something about the gene mutations in your cells that make you more vulnerable to contracting cancer with each passing day.

The encouraging news is that this is now possible with a very simple approach.

Restoring Healthy Gene Function

In recent years, a multitude of studies have shown cancer risk reductions of 50% and greater based on higher vitamin D status.4-9 People with higher vitamin D levels have sharply lower risks of cancers of the breast, prostate, colon, esophagus, pancreas, ovary, rectum, bladder, kidney, lung and uterus, along with non-Hodgkin’s lymphoma and multiple myeloma.4,10-22

What has fascinated us most, however, is that vitamin D protects against cancer by enabling people to regain control over the genes that regulate cell proliferation.

Vitamin D has an effect on at least 200 human genes.22 Many of these genes are responsible for regulating not only cell proliferation, but differentiation and apoptosis as well. Here are simple definitions of these cellular processes:

Proliferation: Uncontrolled cell division (cancer cells are characterized by rapid and uncontrolled division).

Differentiation: Process that cells undergo to mature into normal cells (uncontrolled reproduction of immature cells is a defining feature of cancer).

Apoptosis: Natural termination of defective cells (cancer cells are resistant to natural destruction, making them difficult to eradicate).

With less than optimal vitamin D status, the expression of the genes that regulate the three critical processes above becomes defective.

This means these regulatory genes can no longer maintain healthy cellular function (including programmed termination). The result is sharply

higher cancer risks, as the lack of vitamin D negatively impacts gene expression that controls proliferation, differentiation, and apoptosis of our cells.

So for only pennies a day, we can all achieve optimal vitamin D status and help our cells regain control over genes that protect us against cancer.

For the first time, humans can exert a significant degree of control over a lethal aging process, i.e. gene mutations that are the underlying cause of cancer itself!

Risk of Developing Breast Cancer by Age 2
By age 25: 1 in 19,608

By age 30: 1 in 2,525

By age 40: 1 in 217

By age 45: 1 in 93

By age 50: 1 in 50

By age 55: 1 in 33

By age 60: 1 in 24

By age 65: 1 in 17

By age 70: 1 in 14

By age 75: 1 in 11

By age 80: 1 in 10

By age 85: 1 in 9

Ever: 1 in 8

Breakthrough Study Documents Effectiveness of Vitamin D
While numerous studies show people with higher blood levels of vitamin D have lowered cancer risk, what had been lacking was a doubleblind, placebo-controlled study that specifically measured the effects of higher-dose vitamin D supplementation (with calcium) on cancer incidence in humans.

This is the kind of study that conventional medical doctors insist on seeing if they are to believe a nutrient (or drug) really provides a health benefit.

In a breakthrough report, the effects of administering 1,000 IU a day of vitamin D (with calcium) was evaluated in 1,180 postmenopausal women living in the Midwest.10

After four years, the risk of contracting any cancer was 60% lower in the vitamin D (and calcium) group, compared with the placebo arm of the study.

The scientists then performed an even more detailed analysis of the data.

When excluding cancers diagnosed in the first year of the study, which would have included preexisting cancers present at the time participants began taking vitamin D, they found an astounding 77% reduction in cancer incidence in the group receiving vitamin D, compared with placebo. (Interestingly, in a third arm of this study in which the participants received calcium but no vitamin D, the cancer risk reductions were not as significant.)

What this means is that if all Americans began taking just 1,000 IU of vitamin D each day (with calcium), as many as three-quarters of all cancers could be prevented in just four years.

Not Good Enough!
While a 60% to 77% reduction in cancer incidence in response to taking a moderate dose of vitamin D is impressive, it’s not good enough for us! It would be absurd to ignore the “other” documented factors that increase the incidence of cancer in aging people.

We are going to talk a lot about specific breast cancer-prevention strategies in this article. Please keep in mind, however, that the same approaches that reduce breast cancer risk also lower rates of other common cancers, including cancer of the prostate gland.

Studies that look at human populations (epidemiological studies) have consistently shown that what we eat affects our cancer risk. Women who eat red meat suffer higher breast cancer rates, whereas men who eat red meat have greater prostate cancer rates.23,24 It’s not a coincidence. The same carcinogenic effects that red meat inflicts in breast cells occur in prostate and other cells in the body.

In one of the better documented studies overseen by researchers at prestigious American universities, postmenopausal women in China who ate a Western-style diet (which included beef, pork, and desserts) were 60% more likely to develop breast cancer than those eating a diet based on vegetables and soy.

Even more startling was the finding that in women who contracted estrogen receptor-positive breast tumors, those who ate the Western-style diet experienced a 90% increased risk!25

So what does this tell us when someone says that women should not take natural estrogen and progesterone because of fears of breast and other cancers? It tells us that we should not worry so much about natural hormone balancing, and should focus on the thousands of dangerous calories we are putting into our bodies each day.26

Don’t expect the government to warn you about the carcinogenic effects of common foods. Intense lobbying efforts by the food industry have resulted in the government perpetuating the myth that a “balanced diet” is healthy. The hard facts pulled from hundreds of published studies are that government-sanctioned Western diets are killing us in many ways, including sharply increasing incidences of breast, prostate, and other cancers.

Consuming more plant-derived protein, phytonutrients, and omega-3 fatty acids in place of meat, high-fat dairy, and sugary foods is a good way to cut back on the foods that have been shown to increase breast cancer risk.25,27-29

(For specific information on why these bad foods are so dangerous, refer to the article titled “Eating Your Way to Prostate Cancer” in the February 2007 issue of Life Extension.)

Methods to Reduce Breast and Prostate Cancer Risk: What You Need to Know

The underlying cause of most cancers is the aging process itself. As humans age, they accumulate mutations in the genes that regulate cell proliferation, differentiation, and apoptosis—setting the stage for cancer.

An enlightened cancer-prevention strategy is to utilize nutritional strategies that have been shown to favorably affect gene expression. One of the simplest ways to protect against cancer is to optimize intake of vitamin D.

Minimizing red meat, high-fat dairy, and sweets and consuming more vegetables and soy products can help reduce the risk of breast and other cancers.

Cruciferous vegetable compounds such as indole-3-carbinol can help prevent breast, prostate, and other cancers by favorably altering estrogen metabolism. A simple urine test can confirm that you are consuming the correct amount to ensure optimal cancer protection.

Consuming soy isoflavones is associated with a decreased risk of breast and prostate cancers.

A compound derived from fruits called D-glucarate helps promote the healthy detoxification of estrogen and carcinogens, reducing cancer risk.

Dietary lignans offer outstanding protection against breast, endometrial, and prostate malignancies.

Consuming the right foods and supplements could reduce up to 90% of all cancers.

How Cruciferous Vegetables Protect Against Breast Cancer
There are certain fruits, vegetables and plant extracts that have been shown to protect against breast, prostate, and other cancers.

Scientists have identified compounds in cruciferous vegetables (broccoli, cauliflower, Brussels sprouts, cabbage, kale) that specifically neutralize dangerous breakdown products of estrogen that promote cancer growth.30-35

Cruciferous vegetable compounds also help neutralize the many carcinogens we are inevitably exposed to each day.36,37

One of best studied cruciferous vegetable compounds is called indole-3-carbinol, or I3C for short.

Women seeking to restore youthful hormone balance should make sure to obtain enough I3C from their diet or by taking standardized supplements.

The reason for this is that I3C increases levels of a cancer- protective estrogen metabolite (2-hydroxyestrone, or 2-OHE1), while suppressing a dangerous estrogen metabolite (16 alpha-hydroxyestrone, or 16-OHE1) that promotes breast and other cancers.38,39

To emphasize the critical importance of I3C (and its related compounds), please understand that aging women still produce estrogen, and that the estrogen they supplement with can follow two primary metabolic pathways in the body.

If we convert estrogen to 16 alphahydroxyestrone, then we increase the risk of breast and other cancers.

If on the other hand, we convert estrogen to 2-hydroxyestrone, then we decrease our risk for breast and other cancers.40-42 I3C can readily be obtained by eating lots of cruciferous vegetables and/or taking the proper amount in supplement form.

To confirm the theory that certain estrogen metabolites can contribute to cancer, researchers analyzed data gathered from over 10,000 Italian women over more than five years. The objective was to determine how dietary and hormonal factors influence breast cancer risk.

They found that women were much less likely to develop breast cancer when they had higher levels of 2-hydroxyestrone.40 This same finding has been shown in additional studies of different populations.43,44

The toxic estrogen metabolite 16 alpha-hydroxyestrone acts as a breast tumor promoter.45 By contrast, estrogen metabolized via the 2-hydroxyestrone pathway does not exhibit estrogenic activity in breast tissue. 45 Additionally, a form of this less active estrogen metabolite is believed to prevent the formation of blood vessels necessary to feed growing cancers, thus helping to arrest tumor growth.46

This delicate balance of estrogens is crucially important for men’s health as well. In a study that examined the ratio of estrogen metabolites relative to prostate cancer risk, elevated levels of 16 alpha-hydroxyestrone were linked with an increased risk of prostate cancer.41

Fortunately, the cruciferous vegetable compounds (such as I3C) are effective in shifting estrogen metabolism to the more beneficial pathway, thus reducing levels of toxic 16 alphahydroxyestrone and increasing levels of protective 2-hydroxyestrone.42,45,47,48

This beneficial modulation of estrogen with reduced risk of breast and other cancers, including cervical, prostate, and even head and neck cancers.33,40-42

Cruciferous vegetable compounds thus play an important role in fighting cancer.

The Cancer Prevention Potential of Soy
The latest study showing a remarkable 90% reduction in estrogen receptor-positive breast cancers in women who consumed lots of vegetables and soy (in lieu of a Western-style diet) provides persuasive evidence that compounds found in soy indeed have a breast cancerpreventive effect.25

For the past decade, a controversy has raged over whether people can reduce their risk of cancer by increasing their consumption of soy foods or soy supplements. In response to the debate, a number of studies were initiated in the 1990s to ascertain soy’s effects on human health.

Over the past few years, the results of these studies began to be released. While ignored by the mainstream media, the startling findings indicate that prostate and breast cancer risk could be cut in half if people only consumed more soy.25,49-51

Isoflavones derived from soy have shown great promise in providing natural protection against multipletypes of cancer.52-54 Isoflavones are phytochemical constituents of soy, with two of the best known being genistein and daidzein.

The isoflavones are believed to exert a number of positive biological effects on the human body, and many practitioners of integrative medicine (and even a small but growing number in mainstream medicine) now believe that consumption of soy and isoflavones can reduce the risk of many chronic diseases, including cancer, heart disease, and osteoporosis.49-59

Studies conducted in Asia found that Asian women, who consume many more isoflavones than American women, have significantly lower risks of developing breast cancer.60

Because animal studieshave shown that a diet high in soyand genistein can protect againstmammary, colon, and skin tumors,61it seemed reasonable to think thatsoy could also help prevent humancancers and, in particular, breastcancer.

Yet many mainstream medical practitioners remain skepticalthat something as “simple” as soycould have such a profound effect onhuman health.

Measuring Your Ratio of 2-hydroxyestrone To Toxic 16 alpha-hydroxyestrone
Eating lots of cruciferous vegetables, and/or taking supplements like indole-3-carbinol (I3C) has been shown to increase protective 2-hydroxyestrone and reduce the dangerous estrogen metabolite called 16 alpha-hydroxyestrone.93

If you are taking any kind of estrogen drug (be it natural or synthetic) or are at an increased risk of breast cancer, it is critical to know if you are consuming enough cruciferous vegetables and/or I3C to achieve optimal ratios of these estrogen metabolites (i.e. higher 2-hydroxyestrone in relation to 16 alpha-hydroxyestrone).94

In addition to breast cancer, evidence indicates that this ratio is relevant to other disorders such as osteoporosis.95

Favorable alterations of the 2-hydroxyestrone to 16 alpha-hydroxyestrone ratio have been shown to be associated with lowered incidence of certain estrogen-sensitive cancers.93,96

Dr. Jonathan Wright has worked with Life Extension to make available to you a simple urinary test that can measure your ratio of these two critical estrogen metabolites.

All you have to do is urinate first thing in the morning into the vial you will be sent and return it in the pre-paid postage envelope. You will receive your results with specific recommendations in one to three weeks.

The retail price of this test is $160, but Life Extension members can have it done for only $128.

To order the Urinary 2/16 Estrogen Metabolite Ratio test, just call 1-800-208-3444 (24 hours/day).

Soy, Estrogen, and Breast Cancer
Some in the medical establishment believe that soy isoflavones have no role in preventing serious diseases such as cancer.

Others believe that soy isoflavones should not be used as nutritional supplements because isoflavones act as natural estrogens and could cause many of the same problems—such as increased risk of stroke—that synthetic estrogens are now known to cause.

In fact, soy isoflavones do not simply act as “natural” estrogens. Soy isoflavones are correctly classified as selective estrogen receptor modulators.

Due to their unique molecular structure, soy isoflavones can act as either estrogen receptor agonists or receptor blockers. With this ability, soy isoflavones are thought by many to confer the beneficial effects of estrogen without its potentially dangerous side effects, especially in hormonally sensitive tissues found in both the breast and endometrium.62

Numerous studies show the potential benefits to women of incorporating soy in their diets to help prevent breast cancer. A landmark 1991 casecontrol study of women in Singapore, involving 200 case subjects and 420 control subjects, found that women with the highest consumption of soy-based products had a markedly decreased risk of developing breast cancer.63

An even larger Japanese case-control study in 1995, involving 1,186 subjects and 23,163 controls, also showed that women with increased tofu (soybean curd) intake had a significantly decreased risk of developing breast cancer compared with women who consumed small amounts of soy-based products such as tofu.51

Finally, a very large population-based, prospective study of 21,852 Japanese women aged 40-59 found that women with the highest intake of soy isoflavones reduced their risk of breast cancer by up to 54% compared with women with the lowest intake of soy isoflavones.60

Despite the evidence-based research showing soy isoflavones’ preventive effects on breast cancer, along with epidemiological studies highlighting the much lower rates of breast cancer among Asian women who consume significant amounts of soy-based products, some doctors still caution women against using soy-based foods and supplements.

They contend that because soy isoflavones have been labeled as estrogen “mimics,” they could potentially worsen or even cause breast cancer.

With the current knowledge that soy isoflavones act as selective estrogen receptor modulators and are not simply estrogen “mimics,” these arguments do not hold up.

In addition to being a chemopreventive supplement for breast cancer, soy isoflavones are also thought to be effective in warding off other types of cancer that afflict women, including endometrial cancer.

A recent casecontrol study reported the effects of soy isoflavones and other phytoestrogens on the risk of developing endometrial cancer.64

The study compared 500 women aged 35-79 who developed endometrial cancer between 1996 and 1999 with 470 age- and ethnicity-matched controls.

As in studies examining the effects of isoflavones on breast cancer, this study showed that women with a higher intake of soy isoflavones had a significantly lower risk of developing endometrial cancer.

Even more interesting was that the levels of isoflavones needed to provide protection against endometrial cancer were found to be much lower than the amount believed necessary to protect against breast cancer.

Soy Counteracts Prostate Cancer in Men
Both animal and human studies have shown that soy isoflavones can help protect men from prostate cancer by slowing and even preventing the disease.65,66

Prostate cancer is the most common cancer in men and the second leading cause of death from cancer (after lung cancer) among men.67 As is the case concerning breast cancer in women, large epidemiological studies have shown that Asian men who consume large amounts of soy-based foods have a significantly lower incidence of prostate cancer, compared with their Western counterparts.68

Researchers found that soybean products, as well as other East Asian dietary staples such as fish and tofu, were associated with a decreased risk of prostate cancer in Japanese men.68 Specifically, men who consumed the greatest amounts of soybeans and tofu were 47% and 53% less likely, respectively, to develop prostate cancer than those who consumed the smallest amounts.

Furthermore, in men who consumed the greatest product natto, the prostate cancer incidence was reduced by a remarkable 75%. Finally, in a case-control study published in January 2004, Japanese researchers sought to ascertain whether a high serum concentration of phytoestrogens reduces the risk of prostate cancer. The researchers collected lifestyle information and serum samples from more than 14,000

Japanese men in 1988-90, who were tracked until 1999. Phytoestrogens and sex hormones stored in serum were measured in 2002, and 52 case subjects and 151 controls were identified.

This study clearly established that elevated serum levels of all three phytoestrogens assessed—genistein, daidzein, and equol—imparted a strong protective effect against prostate cancer.69

Men with the highest circulating levels of genistein, daidzein, and equol reduced their risk of prostate cancer by 62%, 59%, and 66%, respectively.

Soy can be added to one’s diet in many ways, and it is increasingly being used in breast health dietary supplement formulas.

Why Fruits are Important
The body is bombarded with carcinogens on a daily basis. These cancer-causing agents include pesticides, over-cooked food, alcohol, food additives, tobacco, fungal mutagens, and industrial pollutants.

While avoiding carcinogens is difficult, it may be possible to mitigate their lethal effects by providing the body with a specific plant extract that facilitates the detoxification and removal of these dangerous substances from the body.

A compound called D-glucarate is found in grapefruit, apples, oranges, broccoli, and Brussels sprouts.70,71 D-Glucarate has been shown to protect against cancer-causing agents by supporting detoxification and removal of dangerous chemicals, and also by protecting against the mutating effects that these carcinogens induce on cellular DNA.72

There are several mechanisms by which the body detoxifies itself. One way of guarding against toxic overload involves a pathway of detoxification in the body whereby carcinogens are combined with water-soluble substances, thus making them more easily removed from the body.

This process is called glucuronidation, and D-glucarate has been shown to support this important detoxification mechanism.72

How Does D-Glucarate Work?
D-Glucarate functions by inhibiting the dangerous beta-glucuronidase enzyme, thus protecting the critical “glucuronidation” detoxification mechanism.

One example of the importance of glucuronidation can be seen in the risk factors for breast cancer.

Excess levels of 16 alphahydroxyestrone and the beta-glucuronidase enzyme are associated with an increased incidence of breast cancer.73

D-Glucarate is thought to decrease estrogen levels by affecting estrogen’s elimination.

Normally, estrogen is conjugated with glucurate in the liver (glucuronidation), and then excreted in the bile.

A bacterial enzyme in the intestine called beta-glucuronidase can break the estrogen-glucuronide bond, allowing estrogen to be reabsorbed.

D-Glucarate works at this step by inhibiting beta-glucuronidase.73

Blocking this enzyme is thought to decrease the amount of estrogen that is reabsorbed and thus to lower circulating estrogen levels.

Research studies have shown that D-glucarate inhibits mammary tumor incidence.74,75

One study in rats that already had breast cancer showed that oral D-glucarate administration resulted in a 50% inhibition of beta-glucuronidase, which led to a 30% reduction in mammary tumor growth during the promotion stage and a four-fold reduction in the absolute number of tumors.76

Another study showed a more than 70% decrease in mammary tumor development in rats exposed to carcinogens who were also administered D-glucarate.77 Still another study looked at the effects of D-glucarate on the initiation and promotional stages of mammary cancer.

The results showed a reduction of 28% during the initiation stage, while cell replication was reduced by 42% during the promotion stage.78

Inhibition at the initiation stage is a very important part of D-glucarate’s actions, as it lessens the risk that cancer will even start.

Eating lots of the right fruits and vegetables supplies the body with D-glucarate. It is also available in dietary supplements designed to support breast health



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